Circulating CA 15.3 as a tumor marker in breast cancer patients: an evaluation of CA 15.3 as a tumour measlier in breast cancer

CA 15. 3 is an antigen expressed by human breast carcinoma cells and defined by two monoclonal antibodies; 115 D[8] and DF[3]. We used Enzyme Linked Immunosorbent Assay [ELISA] to determine the antigen levels in plasma of 50 woman divided into 5 groups; 10 healthy women as controls [Group [I]], 10 patients with benign breast diseases [Group [II]], 10 patients with ovarian, endometrial or cervical [non breast cancer] [Group [Ill]], 10 patients with operable mammary carcinoma [Group [IV]] and a further 10 patients with dissiminated breast carcinoma [Group [V]]. Plasma CA 15. 3 level was [13. 1 +/- 3. 28 u/ml] in. group [I], [10 +/- 4. 03 u/ml] in group [II], [16. 3 +/- 4. 97 u/ml] in group [Ill], [21. 2 +/- 5. 94 V/ml] in group [IV] and [69. 7 +/- 5. 57 u/ml] in group [V]. Our results showed that, circulating CA 15. 3 antigen level agreed with the stage of breast cancer and may be regarded as a useful guide in surveillance of breast cancer patients. Despite this still there is 40% of advanced mamary carcinoma patients had CA 15. 3 levels similar to that of normal healthy control and must be regarded as an antigen negative

lethal and mutagenic effect of N-Methyl-N-Nitroso guanidine [MnnG] on Escherichia coli

Comparing the characters of the mutants and their parent strains, the isolated mutants were found to be different in some morphological and colonial characters, haemolysin production, haemagglutination activity, biochemical reactions and antibiotic sensitivities

Effect of a newly developed hematoporphyrin derivative preparation on oral flora during orthodontic treatment

This study was designed to assess the effect of topical porphyrin application on some bacterial and fungal species of oral flora after using orthodontic treatment [ODT] which indicated to correct abnormalities of the teeth of patient. A novel porphyrin derivative was used. It was concluded that, all Gram-negative strains appeared to be resistant, except neisseria. Gram-positive strains were significantly inhibited due to porphyrin application. Oral fungus as C and ida albicans were significantly inhibited after porphyrin application